Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.

ABSTRACT:

Purpose

To establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related.

Methods

The relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over physiologically relevant dimensions individually, and in combination, using a numerical simulation application. Stepwise multiple regression was used to identify which microstructural features of muscle significantly predict the diffusion tensor using single-echo and multi-echo DTI pulse sequences. Simulations were also performed in models with histology-informed geometry to investigate the relationship between fiber size and the diffusion tensor in models with re

SUBMITTER: Berry DB 

PROVIDER: S-EPMC5876103 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature