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Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda.


ABSTRACT:

SUBMITTER: Martinez L 

PROVIDER: S-EPMC5876110 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

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Effectiveness of WHO's pragmatic screening algorithm for child contacts of tuberculosis cases in resource-constrained settings: a prospective cohort study in Uganda.

Martinez Leonardo L   Shen Ye Y   Handel Andreas A   Chakraburty Srijita S   Stein Catherine M CM   Malone LaShaunda L LL   Boom W Henry WH   Quinn Frederick D FD   Joloba Moses L ML   Whalen Christopher C CC   Zalwango Sarah S  

The Lancet. Respiratory medicine 20171219 4


<h4>Background</h4>Tuberculosis is a leading cause of global childhood mortality; however, interventions to detect undiagnosed tuberculosis in children are underused. Child contact tracing has been widely recommended but poorly implemented in resource-constrained settings. WHO has proposed a pragmatic screening approach for managing child contacts. We assessed the effectiveness of this screening approach and alternative symptom-based algorithms in identifying secondary tuberculosis in a prospect  ...[more]

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