A Statistically Representative Atlas for Mapping Neuronal Circuits in the Drosophila Adult Brain.

ABSTRACT: Imaging the expression patterns of reporter constructs is a powerful tool to dissect the neuronal circuits of perception and behavior in the adult brain of Drosophila, one of the major models for studying brain functions. To date, several Drosophila brain templates and digital atlases have been built to automatically analyze and compare collections of expression pattern images. However, there has been no systematic comparison of performances between alternative atlasing strategies and registration algorithms. Here, we objectively evaluated the performance of different strategies for building adult Drosophila brain templates and atlases. In addition, we used state-of-the-art registration algorithms to generate a new group-wise inter-sex atlas. Our results highlight the

SUBMITTER: Arganda-Carreras I 

PROVIDER: S-EPMC5876320 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature