Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD⁺ in healthy middle-aged and older adults.

ABSTRACT: Nicotinamide adenine dinucleotide (NAD⁺) has emerged as a critical co-substrate for enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As such, the use of NAD⁺ precursors to augment NAD⁺ bioavailability has been proposed as a strategy for improving cardiovascular and other physiological functions with aging in humans. Here we provide the evidence in a 2 × 6-week randomized, double-blind, placebo-controlled, crossover clinical trial that chronic supplementation with the NAD⁺ precursor vitamin, nicotinamide riboside (NR), is well tolerated and effectively stimulates NAD⁺ metabolism in healthy middle-aged and older adults. Our results also provide initial insight into the effects of chronic NR supplem

SUBMITTER: Martens CR 

PROVIDER: S-EPMC5876407 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature