Targeting the Hippo Pathway and Cancer through the TEAD Family of Transcription Factors.

ABSTRACT: The Hippo pathway is a critical transcriptional signaling pathway that regulates cell growth, proliferation and organ development. The transcriptional enhanced associate domain (TEAD) protein family consists of four paralogous transcription factors that function to modulate gene expression in response to the Hippo signaling pathway. Transcriptional activation of these proteins occurs upon binding to the co-activator YAP/TAZ whose entry into the nucleus is regulated by Lats1/2 kinase. In recent years, it has become apparent that the dysregulation and/or overexpression of Hippo pathway effectors is implicated in a wide range of cancers, including prostate, gastric and liver cancer. A large body of work has been dedicated to understanding the therapeutic potential of modulating the phosphoryl

SUBMITTER: Holden JK 

PROVIDER: S-EPMC5876656 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature