Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Combined use of inhaled corticosteroids and long-acting β-agonists (LABAs) as the controller and the quick relief therapy termed single maintenance and reliever therapy (SMART) is a potential therapeutic regimen for the management of persistent asthma.

Objective

To conduct a systematic review and meta-analysis of the effects of SMART in patients with persistent asthma.

Data sources and study selection

The databases of MEDLINE via OVID, EMBASE, the Cochrane Central Register of Controlled Trials, and the Cochrane Database of Systematic Reviews were searched from database inception through August 2016 and updated through November 28, 2017. Two reviewers selected randomized clinical trials or observational studies evaluating SMART vs inhaled corticosteroids wit

SUBMITTER: Sobieraj DM 

PROVIDER: S-EPMC5876810 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature