Uveal Melanoma Associated With Myotonic Dystrophy: A Report of 6 Cases.

ABSTRACT:

Importance

Patients with myotonic dystrophy (MD) have an increased risk of malignancy including uveal melanoma. This case series further explores the association between these 2 diseases.

Objective

To describe a cohort of patients with uveal melanoma associated with MD, including a case of iris melanoma, and MD-associated uveal melanoma in relatives.

Design, setting, and participants

Retrospective case series at 3 tertiary referral centers (Wills Eye Hospital, Philadelphia, Pennsylvania; Mayo Clinic, Rochester, Minnesota; and Moorfields Eye Hospital, London, England), between January 1, 2000, and August 31, 2017. The study included 6 patients with MD and uveal melanoma.

Main outcomes and measures

Melanoma response to treatment and development of metastatic dise

SUBMITTER: Dalvin LA 

PROVIDER: S-EPMC5876914 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature