Dataset Information

Nanoparticles engineered to bind cellular motors for efficient delivery.

ABSTRACT:

Background

Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications.

Results

Here, we show that gold nanoparticles modified with dynein-binding delivery sequences become mobile, powered by molecular motor proteins. Modified nanoparticles showed dynamic properties, such as travelling the cytosol, crossing intracellular barriers and shuttling the nuclear membrane. Furthermore, nanoparticles were transported from one cell to another through cell-to-cell contacts and quickly spread to distant cells through cell projections.

Conclusions

The capacity of these motor-bound nanoparticles to spread to many cells and increasing cellular retention, thus avoiding losses and allowing lower dosage, could make them candidate carriers for drug delivery.

SUBMITTER: Dalmau-Mena I

PROVIDER: S-EPMC5877387 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature

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Publications

Nanoparticles engineered to bind cellular motors for efficient delivery.

Dalmau-Mena Inmaculada I Del Pino Pablo P Pelaz Beatriz B Cuesta-Geijo Miguel Ángel MÁ Galindo Inmaculada I Moros María M de la Fuente Jesús M JM Alonso Covadonga C

Journal of nanobiotechnology 20180330 1

<h4>Background</h4>Dynein is a cytoskeletal molecular motor protein that transports cellular cargoes along microtubules. Biomimetic synthetic peptides designed to bind dynein have been shown to acquire dynamic properties such as cell accumulation and active intra- and inter-cellular motion through cell-to-cell contacts and projections to distant cells. On the basis of these properties dynein-binding peptides could be used to functionalize nanoparticles for drug delivery applications.<h4>Results< ...[more]

PMID: 29602307

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Dataset Information

Nanoparticles engineered to bind cellular motors for efficient delivery.

Background

Results

Conclusions

Publications

Nanoparticles engineered to bind cellular motors for efficient delivery.

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