Pharmacogenetics of Ketamine-Induced Emergence Phenomena: A Pilot Study.

ABSTRACT:

Background

Up to 55% of patients who are administered ketamine experience an emergence phenomena (EP) that closely mimics schizophrenia and increases their risk of injury; however, to date, no studies have investigated genetic association of ketamine-induced EP in healthy patients.

Objectives

The aim of the study was to investigate the feasibility and sample sizes required to explore the relationship between CYP2B6*6 and GRIN2B single-nucleotide polymorphisms and ketamine-induced EP.

Methods

This cross-sectional, pharmacogenetic candidate, gene pilot study recruited 75 patients having minor elective outpatient surgeries. EP was measured with the Clinician Administered Dissociative State Scale. Genetic association of CYP2B6*6 and GRIN2B (rs1019385 and rs1806191) single

SUBMITTER: Aroke EN 

PROVIDER: S-EPMC5877453 | biostudies-literature | 2017 Mar/Apr

REPOSITORIES: biostudies-literature