The development of AZD7624 for prevention of exacerbations in COPD: a randomized controlled trial.

ABSTRACT:

Background

p38 mitogen-activated protein kinase (MAPK) plays a central role in the regulation and activation of pro-inflammatory mediators. COPD patients have increased levels of activated p38 MAPK, which correlate with increased lung function impairment, alveolar wall inflammation, and COPD exacerbations.

Objectives

These studies aimed to assess the effect of p38 inhibition with AZD7624 in healthy volunteers and patients with COPD. The principal hypothesis was that decreasing lung inflammation via inhibition of p38α would reduce exacerbations and improve quality of life for COPD patients at high risk for acute exacerbations.

Methods

The p38 isoform most relevant to lung inflammation was assessed using an in situ proximity ligation assay in severe COPD patients and do

SUBMITTER: Patel NR 

PROVIDER: S-EPMC5877500 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature