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Role and inhibition of GLI1 protein in cancer.

ABSTRACT: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non-small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies.

SUBMITTER: Mastrangelo E 

PROVIDER: S-EPMC5877502 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Role and inhibition of GLI1 protein in cancer.

Mastrangelo Eloise E   Milani Mario M  

Lung Cancer (Auckland, N.Z.) 20180327

GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non-small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising st  ...[more]

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