Ontology highlight
ABSTRACT:
SUBMITTER: Hu F
PROVIDER: S-EPMC5877504 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Hu Fanlei F Zhang Wei W Shi Lianjie L Liu Xu X Jia Yuan Y Xu Liling L Zhu Huaqun H Li Yingni Y Xu Dakang D Lu Liwei L Qiu Xiaoyan X Liu Wanli W Qiao Junjie J Wang Yongfu Y Li Zhanguo Z
Frontiers in immunology 20180323
Natural antibodies, particularly natural IgM, are proved to play indispensable roles in the immune defenses against common infections. More recently, the protective roles of these natural IgM were also recognized in autoimmune diseases. They are mainly produced by B-1 and innate-like B cells (ILBs). Human CD19<sup>+</sup>CD27<sup>+</sup>IgD<sup>+</sup> B cells, also termed as un-switched memory B cells, were proposed to be a kind of ILBs. However, functional features and characteristics of these ...[more]