Therapeutics in Osteoarthritis Based on an Understanding of Its Molecular Pathogenesis.

ABSTRACT: Osteoarthritis (OA) is the most prevalent joint disease in older people and is characterized by the progressive destruction of articular cartilage, synovial inflammation, changes in subchondral bone and peri-articular muscle, and pain. Because our understanding of the aetiopathogenesis of OA remains incomplete, we haven't discovered a cure for OA yet. This review appraises novel therapeutics based on recent progress in our understanding of the molecular pathogenesis of OA, including pro-inflammatory and pro-catabolic mediators and the relevant signalling mechanisms. The changes in subchondral bone and peri-articular muscle accompanying cartilage damage are also reviewed.

SUBMITTER: Kim JR 

PROVIDER: S-EPMC5877535 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature