The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

ABSTRACT: Gap junction transmembrane channels allow the transfer of small molecules between the cytoplasm of adjacent cells. They are formed by proteins named connexins (Cxs) that have long been considered as a tumor suppressor. This widespread view has been challenged by recent studies suggesting that the role of Connexin 43 (Cx43) in cancer is tissue- and stage-specific and can even promote tumor progression. High throughput profiling of invasive breast cancer has allowed for the construction of subtyping schemes that partition patients into at least four distinct intrinsic subtypes. This study characterizes Cx43 expression during cancer progression with each of the tumor subtypes using a compendium of publicly available gene expression data. In particular, we show that Cx43 expression depends gre

SUBMITTER: Busby M 

PROVIDER: S-EPMC5877554 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature