ABC Transporters and Their Role in the Neoadjuvant Treatment of Esophageal Cancer.

ABSTRACT: The prognosis of esophageal cancer (EC) is poor, despite considerable effort of both experimental scientists and clinicians. The tri-modality treatment consisting of neoadjuvant chemoradiation followed by surgery has remained the gold standard over decades, unfortunately, without significant progress in recent years. Suitable prognostic factors indicating which patients will benefit from this tri-modality treatment are missing. Some patients rapidly progress on the neoadjuvant chemoradiotherapy, which is thus useless and sometimes even harmful. At the same time, other patients achieve complete remission on neoadjuvant chemoradiotherapy and subsequent surgery may increase their risk of morbidity and mortality. The prognosis of patients ranges from excellent to extremely poor. Considering th

SUBMITTER: Vrana D 

PROVIDER: S-EPMC5877729 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature