Genetic and Epigenetic Regulation in Nonalcoholic Fatty Liver Disease (NAFLD).

ABSTRACT: Genetics and epigenetics play a key role in the development of several diseases, including nonalcoholic fatty liver disease (NAFLD). Family studies demonstrate that first degree relatives of patients with NAFLD are at a much higher risk of the disease than the general population. The development of the Genome Wide Association Study (GWAS) technology has allowed the identification of numerous genetic polymorphisms involved in the evolution of diseases (e.g., PNPLA3, MBOAT7). On the other hand, epigenetic changes interact with inherited risk factors to determine an individual's susceptibility to NAFLD. Modifications of the histones amino-terminal ends are key factors in the maintenance of chromatin structure and gene expression (cAMP-responsive element binding protein H (CREBH) or SIRT1). Ac

SUBMITTER: Del Campo JA 

PROVIDER: S-EPMC5877772 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature