Lithography-free fabrication of reconfigurable substrate topography for contact guidance.

ABSTRACT: Mammalian cells detect and respond to topographical cues presented in natural and synthetic biomaterials both in vivo and in vitro. Micro- and nano-structures influence the adhesion, morphology, proliferation, migration, and differentiation of many phenotypes. Although the mechanisms that underpin cell-topography interactions remain elusive, synthetic substrates with well-defined micro- and nano-structures are important tools to elucidate the origin of these responses. Substrates with reconfigurable topography are desirable because programmable cues can be harmonized with dynamic cellular responses. Here we present a lithography-free fabrication technique that can reversibly present topographical cues using an actuation mechanism that minimizes the confounding effects of applied stimuli. T

SUBMITTER: Pholpabu P 

PROVIDER: S-EPMC5877799 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature