Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

ABSTRACT: The HIV-1 envelope protein (Env) of early-replicating viruses encodes several distinct transmission signatures. One such signature involves a reduced number of potential N-linked glycosylation sites (PNGs). This transmission signature underscores the importance of posttranslational modifications in the fitness of early-replicating isolates. An additional signature in Env involves the overrepresentation of basic amino acid residues at a specific position in the Env signal peptide (SP). In this report, we investigated the potential impact of this SP signature on gp120 glycosylation and antigenicity. Two recombinant gp120s were constructed, one derived from an isolate that lacks this signature and a second from an early-replicating isolate that includes this signature. Chimeric gp120s were al

SUBMITTER: Yolitz J 

PROVIDER: S-EPMC5877976 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature