Role of glutathione metabolism in host defense against Borrelia burgdorferi infection.

ABSTRACT: Pathogen-induced changes in host cell metabolism are known to be important for the immune response. In this study, we investigated how infection with the Lyme disease-causing bacterium Borrelia burgdorferi (Bb) affects host metabolic pathways and how these metabolic pathways may impact host defense. First, metabolome analysis was performed on human primary monocytes from healthy volunteers, stimulated for 24 h with Bb at low multiplicity of infection (MOI). Pathway analysis indicated that glutathione (GSH) metabolism was the pathway most significantly affected by Bb Specifically, intracellular levels of GSH increased on average 10-fold in response to Bb exposure. Furthermore, these changes were found to be specific, as they were not seen during stimulatio

SUBMITTER: Kerstholt M 

PROVIDER: S-EPMC5877983 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature