Benefit Versus Risk Assessment of Rotavirus Vaccination in France: A Simulation and Modeling Analysis.

ABSTRACT:

Introduction

Two vaccines against rotavirus gastroenteritis (RVGE) in young children, Rotarix and RotaTeq, have been available in Europe since 2006. Vaccination against rotaviruses significantly reduces the burden of RVGE, but it is also associated with a very small increased risk of intussusception. In a benefit-risk analysis, the prevented RVGE burden is weighed against the possible excess of intussusception.

Purpose

The aim was to compare the estimated benefits and risks of Rotarix vaccination in France.

Methods

We estimated the benefits (vaccine-preventable RVGE hospitalizations and deaths) and risks (vaccine-caused intussusception hospitalizations and deaths) following two doses of Rotarix in a birth cohort of 791,183 followed for 3-5 years in France. We used dat

SUBMITTER: Ledent E 

PROVIDER: S-EPMC5878204 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature