Idiopathic gastroparesis is associated with specific transcriptional changes in the gastric muscularis externa.

ABSTRACT:

Background

The molecular changes that occur in the stomach that are associated with idiopathic gastroparesis are poorly described. The aim of this study was to use quantitative analysis of mRNA expression to identify changes in mRNAs encoding proteins required for the normal motility functions of the stomach.

Methods

Full-thickness stomach biopsy samples were collected from non-diabetic control subjects who exhibited no symptoms of gastroparesis and from patients with idiopathic gastroparesis. mRNA was isolated from the muscularis externa and mRNA expression levels were determined by quantitative reverse transcriptase (RT)-PCR.

Key results

Smooth muscle tissue from idiopathic gastroparesis patients had decreased expression of mRNAs encoding several contractile protein

SUBMITTER: Herring BP 

PROVIDER: S-EPMC5878698 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature