Comparison of the effect of daily versus bolus dose maternal vitamin D₃ supplementation on the 24,25-dihydroxyvitamin D₃ to 25-hydroxyvitamin D₃ ratio.

ABSTRACT:

Objective

Supplementing lactating mothers with high doses of vitamin D₃ can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D₃ dosing in lactating mothers on vitamin D₃ catabolism. We hypothesized that catabolism of 25(OH)D₃ to 24,25(OH)₂D₃ would be greater in the bolus than in the daily dose group.

Design, setting and patients

Randomized controlled trial (clinicaltrials.govNCT01240265) in 40 lactating women.

Interventions

Subjects were randomized to receive vitamin D₃ orally, either a single dose of 150,000IU or 5000IU daily for 28days. Vitamin D metabolites were measured in serum and breast milk at baseline, 1, 3, 7, 14 an

SUBMITTER: Ketha H 

PROVIDER: S-EPMC5878742 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature