Are amniotic fluid neutrophils in women with intraamniotic infection and/or inflammation of fetal or maternal origin?

ABSTRACT:

Background

Neutrophils are the most abundant white blood cells found in the amniotic cavity of women with intraamniotic infection and/or inflammation. The current belief is that these neutrophils are of fetal origin. However, abundant neutrophils have been found in the amniotic fluid of women with a severe acute maternal inflammatory response but without a severe fetal inflammatory response in the placenta, suggesting that these innate immune cells can also be of maternal origin or a mixture of both fetal and maternal neutrophils.

Objective

We sought to investigate the origin of amniotic fluid neutrophils from women with intraamniotic infection and/or inflammation and to correlate these findings with acute histologic maternal and fetal inflammatory responses in the placenta.

SUBMITTER: Gomez-Lopez N 

PROVIDER: S-EPMC5878926 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature