Closed-Loop Deep Brain Stimulation for Refractory Chronic Pain.

ABSTRACT: Pain is a subjective experience that alerts an individual to actual or potential tissue damage. Through mechanisms that are still unclear, normal physiological pain can lose its adaptive value and evolve into pathological chronic neuropathic pain. Chronic pain is a multifaceted experience that can be understood in terms of somatosensory, affective, and cognitive dimensions, each with associated symptoms and neural signals. While there have been many attempts to treat chronic pain, in this article we will argue that feedback-controlled 'closed-loop' deep brain stimulation (DBS) offers an urgent and promising route for treatment. Contemporary DBS trials for chronic pain use "open-loop" approaches in which tonic stimulation is delivered with fixed parameters to a single brain region. The impa

SUBMITTER: Shirvalkar P 

PROVIDER: S-EPMC5879131 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature