Ezh2 Regulates Activation-Induced CD8⁺ T Cell Cycle Progression via Repressing Cdkn2a and Cdkn1c Expression.

ABSTRACT: Transition from resting to cell cycle in response to antigenic stimulation is an essential step for naïve CD8⁺ T cells to differentiate to effector and memory cells. Leaving the resting state requires dramatic changes of chromatin status in the key cell cycle inhibitors but the details of these concerted events are not fully elucidated. Here, we showed that Ezh2, an enzymatic component of polycomb repressive complex 2 (PRC2) catalyzing the trimethylation of lysine 27 on histone 3 (H3K27me3), regulates activation induced naïve CD8⁺ T cells proliferation and apoptosis. Upon deletion of Ezh2 during thymocyte development (Ezh2^fl/flCd4Cre⁺ mice), naive CD8⁺ T cells displayed impaired proliferation and increased apoptosis in response to anti

SUBMITTER: Chen G 

PROVIDER: S-EPMC5879148 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature