Association of polymorphism rs1053005 in STAT3 with chronic hepatitis B virus infection in Han Chinese population.

ABSTRACT:

Background

Signal transducer and activator of transcription 3 (STAT3) is involved in hepatitis B virus (HBV) infection and HBV-related hepatocellular carcinoma (HCC). The association between polymorphism rs1053005 and haplotypes formed by rs1053004 and rs1053005 in the 3'UTR of STAT3 and chronic HBV infection has yet to be investigated.

Methods

This study included 567 patients with chronic HBV infection (239 chronic hepatitis, 141 liver cirrhosis and 187 HCC), 98 HBV infection resolvers, and 169 healthy controls. STAT3 rs1053004 and rs1053005 polymorphisms were genotyped by TaqMan SNP Genotyping Assays.

Results

The rs1053004 genotype CC [P value by Bonferroni correction (P _c ) = 0.002] and allele C (P _c  = 0.019) were more frequent in patients wi

SUBMITTER: Li M 

PROVIDER: S-EPMC5879595 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature