Deletion of dopamine D₂ receptors from parvalbumin interneurons in mouse causes schizophrenia-like phenotypes.

ABSTRACT: Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The dopaminergic hypothesis was postulated after the finding that antipsychotics were effective to halt increased dopamine tone. However, there is little evidence for dysfunction within the dopaminergic system itself. Alternatively, it has been proposed that excessive afferent activity onto ventral tegmental area dopaminergic neurons, particularly from the ventral hippocampus, increase dopamine neurotransmission, leading to psychosis. Here, we show that selective dopamine D₂ receptor deletion from parvalbumin interneurons in mouse causes an impaired inhibitory activity in the ventral hippocampus and a dysregulated dopaminergic system. C

SUBMITTER: Tomasella E 

PROVIDER: S-EPMC5879696 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature