Epigenetic modifications in KDM lysine demethylases associate with survival of early-stage NSCLC.

ABSTRACT:

Background

KDM lysine demethylase family members are related to lung cancer clinical outcomes and are potential biomarkers for chemotherapeutics. However, little is known about epigenetic alterations in KDM genes and their roles in lung cancer survival.

Methods

Tumor tissue samples of 1230 early-stage non-small cell lung cancer (NSCLC) patients were collected from the five independent cohorts. The 393 methylation sites in KDM genes were extracted from epigenome-wide datasets and analyzed by weighted random forest (Ranger) in discovery phase and validation dataset, respectively. The variable importance scores (VIS) for the sites in top 5% of both discovery and validation sets were carried forward for Cox regression to further evaluate the association with

SUBMITTER: Wei Y 

PROVIDER: S-EPMC5879927 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature