Dynamics of DNMT3A mutation and prognostic relevance in patients with primary myelodysplastic syndrome.

ABSTRACT:

Background

DNMT3A gene mutation has been associated with poor prognosis in acute myeloid leukemia, but its clinical implications in myelodysplastic syndrome (MDS) and dynamic changes during disease progression remain controversial.

Results

In this study, DNMT3A mutation was identified in 7.9% of 469 de novo MDS patients. DNMT3A-mutated patients had higher platelet counts at diagnosis, and patients with ring sideroblasts had the highest incidence of DNMT3A mutations, whereas those with multilineage dysplasia had the lowest incidence. Thirty-one (83.8%) of 37 DNMT3A-mutated patients had additional molecular abnormalities at diagnosis, and DNMT3A mutation was highly associated with mutations of IDH2 and SF3B1. Patients wit

SUBMITTER: Lin ME 

PROVIDER: S-EPMC5879939 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature