Multiplatform plasma fingerprinting in cancer cachexia: a pilot observational and translational study.

ABSTRACT:

Background

Cachexia is a metabolic syndrome that affects up to 50-80% of cancer patients. The pathophysiology is characterized by a variable combination of reduced food intake and abnormal metabolism, including systemic inflammation and negative protein and energy balance. Despite its high clinical significance, defined diagnostic criteria and established therapeutic strategies are lacking. The 'omics' technologies provide a global view of biological systems. We hypothesize that blood-based metabolomics might identify findings in cachectic patients that could provide clues to gain knowledge on its pathophysiology, and eventually postulate new therapeutic strategies.

Methods

This is a cross-sectional observational study in two cohorts of cancer patients, with and without cach

SUBMITTER: Cala MP 

PROVIDER: S-EPMC5879957 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature