MiR-424-5p reduces ribosomal RNA and protein synthesis in muscle wasting.

ABSTRACT:

Background

A loss of muscle mass occurs as a consequence of a range of chronic and acute diseases as well as in older age. This wasting results from an imbalance of protein synthesis and degradation with a reduction in synthesis and resistance to anabolic stimulation often reported features. Ribosomes are required for protein synthesis, so changes in the control of ribosome synthesis are potential contributors to muscle wasting. MicroRNAs (miRNAs) are known regulators of muscle phenotype and have been shown to modulate components of the protein synthetic pathway. One miRNA that is predicted to target a number of components of protein synthetic pathway is miR-424-5p, which is elevated in the quadriceps of patients with chronic obstructive pulmonary disease (COPD).

Methods

Tar

SUBMITTER: Connolly M 

PROVIDER: S-EPMC5879973 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature