Type III interferon is a critical regulator of innate antifungal immunity.

ABSTRACT: Type III interferons (IFN-λs) are the most recently found members of the IFN cytokine family and engage IFNLR1 and IL10R2 receptor subunits to activate innate responses against viruses. We have identified IFN-λs as critical instructors of antifungal neutrophil responses. Using Aspergillus fumigatus (Af) as a model to study antifungal immune responses, we found that depletion of CCR2⁺ monocytes compromised the ability of neutrophils to control invasive fungal growth. Using an unbiased approach, we identified type I and III IFNs as critical regulators of the interplay between monocytes and neutrophils responding to Af We found that CCR2⁺ monocytes are an important early source of type I IFNs that prime optimal expression of IFN-λ. Type III IFNs act

SUBMITTER: Espinosa V 

PROVIDER: S-EPMC5880030 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature