Endocytic recycling via the TGN underlies the polarized hyphal mode of life.

ABSTRACT: Intracellular traffic in Aspergillus nidulans hyphae must cope with the challenges that the high rates of apical extension (1μm/min) and the long intracellular distances (>100 μm) impose. Understanding the ways in which the hyphal tip cell coordinates traffic to meet these challenges is of basic importance, but is also of considerable applied interest, as fungal invasiveness of animals and plants depends critically upon maintaining these high rates of growth. Rapid apical extension requires localization of cell-wall-modifying enzymes to hyphal tips. By combining genetic blocks in different trafficking steps with multidimensional epifluorescence microscopy and quantitative image analyses we demonstrate that polarization of the essential chitin-synthase ChsB occurs by indirect endocytic recy

SUBMITTER: Hernandez-Gonzalez M 

PROVIDER: S-EPMC5880334 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature