Body mass index and weight change during initial period of chemotherapy affect survival outcome in advanced biliary tract cancer patients.

ABSTRACT:

Background

The impact of obesity on survival is known to vary in different cancers. Advanced biliary tract cancer was rarely analyzed about the relationship between obesity and prognosis. We performed this study to evaluate the BMI and body weight change as prognostic factors for advanced biliary tract cancer patients with palliative chemotherapy.

Methods

Between January 2005 and December 2016, two hundred and seventy-six patients who underwent chemotherapy for biliary tract cancer were retrospectively analyzed. The relationship between BMI (kg/m2) and clinical outcomes including overall and progression-free survival was assessed. Additionally the relationship between change in body composition and overall survival was evaluated.

Results

Median overall survival was 9.

SUBMITTER: Kang J 

PROVIDER: S-EPMC5880377 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature