Differential clinicopathological and molecular features within late-onset colorectal cancer according to tumor location.

ABSTRACT:

Background

Since there is a predilection of some clinical and molecular features for a given tumor location, we assessed whether this can be confirmed in late-onset colorectal cancer (LOCRC).

Results

Right colon cancers showed features associated with sporadic Microsatellite Instability: predominance of female cases and BRAF mutations, and an important mucinous component. Left colon cancers developed a higher number of polyps and multiple primary CRCs, showed the strongest familial component, and had better prognosis. Rectal cancers showed a predominantly sporadic phenotype, with worse prognosis and a CpG Island Methylator Phenotype (CIMP)-High. No copy number alterations (CNAs) greater than or equal to 50% were observed in this LOCRC group, and the most recurrent alt

SUBMITTER: Brandariz L 

PROVIDER: S-EPMC5880605 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature