JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
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ABSTRACT:
SUBMITTER: Song X
PROVIDER: S-EPMC5880694 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
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JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice.
Song Xinxin X Zhu Shan S Xie Yangchun Y Liu Jiao J Sun Lingyi L Zeng Dexing D Wang Pengcheng P Ma Xiaochao X Kroemer Guido G Bartlett David L DL Billiar Timothy R TR Lotze Michael T MT Zeh Herbert J HJ Kang Rui R Tang Daolin D
Gastroenterology 20171214 5
<h4>Background & aims</h4>Maintenance of acid-base homeostasis is required for normal physiology, metabolism, and development. It is not clear how cell death is activated in response to changes in pH. We performed a screen to identify agents that induce cell death in a pH-dependent manner (we call this alkaliptosis) in pancreatic ductal adenocarcinoma cancer (PDAC) cells and tested their effects in mice.<h4>Methods</h4>We screened a library of 254 compounds that interact with G-protein-coupled r ...[more]
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