Associations of lipoproteins with cardiovascular and infection-related outcomes in patients receiving hemodialysis.

ABSTRACT:

Background

In hemodialysis (HD) patients, higher lipid levels are associated with lower mortality. Lipid-lowering therapy does not reduce all-cause mortality or cardiovascular (CV) mortality. Lipoproteins play a role in the innate immune system. Our objective was to determine whether protection from infection might counterbalance adverse CV outcomes associated with lipoproteins.

Methods

We examined associations between serum apolipoprotein (Apo) A1, B, C2, C3, high-density lipoprotein and low-density lipoprotein (LDL) cholesterol and triglyceride levels and infectious mortality or hospitalization, CV mortality or hospitalization, and all-cause mortality in 433 prevalent HD patients. Cox models with time-varying apolipoprotein concentrations collected every 6 months for up to

SUBMITTER: Kaysen GA 

PROVIDER: S-EPMC5880742 | biostudies-literature | 2018 Mar - Apr

REPOSITORIES: biostudies-literature