End-stage renal disease after pediatric heart transplantation: A 25-year national cohort study.

ABSTRACT:

Background

End-stage renal disease (ESRD), defined as the need for chronic dialysis and/or kidney transplantation (KTx), is a known complication after heart transplant (HTx). However, factors associated with ESRD are not well elucidated. The objectives of this study were to determine the prevalence, risk factors, and outcomes associated with ESRD after pediatric HTx.

Methods

Scientific Registry of Transplant Recipients data were linked, using direct identifiers, to the United States Renal Data System to identify patients (aged ≤ 18 years) who underwent primary HTx between 1989 and 2013. Risk factors for ESRD and death were analyzed using Cox regression analysis.

Results

Combining the above 2 databases identified ~25% additional HTx patients who developed ESRD that wer

SUBMITTER: Choudhry S 

PROVIDER: S-EPMC5880747 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature