Glycosylation of Immunoglobulin G Associates With Clinical Features of Inflammatory Bowel Diseases.

ABSTRACT:

Background and aims

Causes of inflammatory bowel diseases are not well understood and the most prominent forms, Crohn's disease (CD) and ulcerative colitis (UC), are sometimes hard to distinguish. Glycosylation of IgG has been associated with CD and UC. IgG Fc-glycosylation affects IgG effector functions. We evaluated changes in IgG Fc-glycosylation associated with UC and CD, as well as with disease characteristics in different patient groups.

Methods

We analyzed 3441 plasma samples obtained from 2 independent cohorts of patients with CD (874 patients from Italy and 391 from the United States) or UC (1056 from Italy and 253 from the US and healthy individuals [controls]; 427 in Italy and 440 from the United States). IgG Fc-glycosylation (tryptic glycopeptides) was analyzed b

SUBMITTER: Simurina M 

PROVIDER: S-EPMC5880750 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature