Transferable Plasmid-Borne mcr-1 in a Colistin-Resistant Shigella flexneri Isolate.

ABSTRACT: Since the initial discovery of mcr-1 in an Escherichia coli isolate from China, the gene has also been detected in Klebsiella pneumoniae and Salmonella enterica but is rarely reported in other Enterobacteriaceae Here, we report the isolation and identification of a Shigella flexneri strain harboring mcr-1 from stool samples in a pig farm in China from 2009. The MIC of colistin for the isolate is 4 μg/ml. Conjugation assays showed that the donor S. flexneri strain has functional and transferable colistin resistance. Sequencing revealed that mcr-1 was present on a putative composite transposon flanked by inverted repeats of ISApl1IMPORTANCE There are four species of Shigella, and Shigella flexneri is t

SUBMITTER: Liang B 

PROVIDER: S-EPMC5881045 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature