Altered Proteome of Extracellular Vesicles Derived from Bladder Cancer Patients Urine.

ABSTRACT: Proteomic analysis of extracellular vesicles (EVs) from biological fluid is a powerful approach to discover potential biomarkers for human diseases including cancers, as EV secreted to biological fluids are originated from the affected tissue. In order to investigate significant molecules related to the pathogenesis of bladder cancer, EVs were isolated from patient urine which was analyzed by mass spectrometry based proteomics. Comparison of the EV proteome to the whole urine proteome demonstrated an increased number of protein identification in EV. Comparative MS analyses of urinary EV from control subjects and bladder cancer patients identified a total of 1,222 proteins. Statistical analyses provided 56 proteins significantly increased in bladder cancer urine, including proteins for whic

SUBMITTER: Lee J 

PROVIDER: S-EPMC5881091 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature