A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain.

ABSTRACT: Murine colitis models are crucial tools for understanding intestinal homeostasis and inflammation. However, most current models utilize a highly inbred strain of mice, and often only one sex is employed to limit bias. This targeted approach, which in itself is biased, means that murine genetic diversity and sex-related differences are ignored, making it even more difficult to extend findings to humans, who are highly heterogeneous. Furthermore, most models do not examine the chronic form of colitis, an important fact taking into account the chronic nature of the inflammatory bowel diseases (IBD). Here, we attempted to create a more realistic murine colitis model by addressing these three issues. Using chemically induced chronic colon inflammation in an outbred strain of mice (RjOrl:SWISS [

SUBMITTER: Barone M 

PROVIDER: S-EPMC5881104 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature