Defining adrenarche in the rhesus macaque (Macaca mulatta), a non-human primate model for adrenal androgen secretion.

ABSTRACT: Adrenarche, defined as a prepubertal increase in adrenal androgen secretion resulting from zona reticularis (ZR) maturation, is thought to occur only in humans and some Great Apes. In the rhesus macaque, studies of circulating dehydroepiandrosterone (DHEA) or its sulpho-conjugate (DHEAS) have failed to demonstrate a prepubertal rise typical of human adrenarche, but available data are cross-sectional and include few neonatal or early infant samples. However, ZR maturation is complete in rhesus infants by 3 months of age based on morphological and biochemical analyses. Furthermore, preliminary longitudinal studies from birth through infancy of castrated males, and intact males and females, suggests for the first time that there is a transient, prepubertal elevation of adrenal androgen in rhe

SUBMITTER: Conley AJ 

PROVIDER: S-EPMC5881168 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature