Ontology highlight
ABSTRACT:
SUBMITTER: da Silva LB
PROVIDER: S-EPMC5881292 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
da Silva Ludmila B LB Menezes Milene C MC Kitano Eduardo S ES Oliveira Ana K AK Abreu Afonso G AG Souza Gisele O GO Heinemann Marcos B MB Isaac Lourdes L Fraga Tatiana R TR Serrano Solange M T SMT Barbosa Angela S AS
Frontiers in cellular and infection microbiology 20180327
Leptospires are highly motile spirochetes equipped with strategies for efficient invasion and dissemination within the host. Our group previously demonstrated that pathogenic leptospires secrete proteases capable of cleaving and inactivating key molecules of the complement system, allowing these bacteria to circumvent host's innate immune defense mechanisms. Given the successful dissemination of leptospires during infection, we wondered if such proteases would target a broader range of host mole ...[more]