Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection.

ABSTRACT: Immune-Responsive Gene 1 (Irg1) is a mitochondrial enzyme that produces itaconate under inflammatory conditions, principally in cells of myeloid lineage. Cell culture studies suggest that itaconate regulates inflammation through its inhibitory effects on cytokine and reactive oxygen species production. To evaluate the functions of Irg1 in vivo, we challenged wild-type (WT) and Irg1^-/- mice with Mycobacterium tuberculosis (Mtb) and monitored disease progression. Irg1^-/-, but not WT, mice succumbed rapidly to Mtb, and mortality was associated with increased infection, inflammation, and pathology. Infection of LysM-Cre Irg1^fl/fl, Mrp8-Cre Irg1^fl/fl, and CD11c-Cre Irg1^f

SUBMITTER: Nair S 

PROVIDER: S-EPMC5881474 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature