Insidious Risk of Severe Mycobacterium chimaera Infection in Cardiac Surgery Patients.

ABSTRACT:

Background

An urgent UK investigation was launched to assess risk of invasive Mycobacterium chimaera infection in cardiothoracic surgery and a possible association with cardiopulmonary bypass heater-cooler units following alerts in Switzerland and The Netherlands.

Methods

Parallel investigations were pursued: (1) identification of cardiopulmonary bypass-associated M. chimaera infection through national laboratory and hospital admissions data linkage; (2) cohort study to assess patient risk; (3) microbiological and aerobiological investigations of heater-coolers in situ and under controlled laboratory conditions; and (4) whole-genome sequencing of clinical and environmental isolates.

Results

Eighteen probable cases of cardiopulmonary bypass-associated M. chimaera infec

SUBMITTER: Chand M 

PROVIDER: S-EPMC5881635 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature