Cannabinoid Receptor-2 Ameliorates Inflammation in Murine Model of Crohn's Disease.

ABSTRACT:

Background and aims

Cannabinoid receptor stimulation may have positive symptomatic effects on inflammatory bowel disease [IBD] patients through analgesic and anti-inflammatory effects. The cannabinoid 2 receptor [CB2R] is expressed primarily on immune cells, including CD4+ T cells, and is induced by active inflammation in both humans and mice. We therefore investigated the effect of targeting CB2R in a preclinical IBD model.

Methods

Employing a chronic ileitis model [TNFΔARE/+ mice], we assessed expression of the CB2R receptor in ileal tissue and on CD4+ T cells and evaluated the effect of stimulation with CB2R-selective ligand GP-1a both in vitro and in vivo. Additionally, we compared cannabinoid receptor expression in the ilea and colons of healthy human controls with that

SUBMITTER: Leinwand KL 

PROVIDER: S-EPMC5881726 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature