Epigenetic and Posttranscriptional Regulation of CD16 Expression during Human NK Cell Development.

ABSTRACT: The surface receptor FcγRIIIA (CD16a) is encoded by the FCGR3A gene and is acquired by human NK cells during maturation. NK cells bind the Fc portion of IgG via CD16a and execute Ab-dependent cell-mediated cytotoxicity, which is critical for the effectiveness of several antitumor mAb therapies. The role of epigenetic regulatory mechanisms controlling transcriptional and posttranscriptional CD16 expression in NK cells is unknown. In this study, we compared specific patterns of DNA methylation and expression of FCGR3A with FCGR3B, which differ in cell type-specific expression despite displaying nearly identical genomic sequences. We identified a sequence within the FCGR3A promoter that selectively exhibits reduced methylation in CD16a⁺ NK cells versus C

SUBMITTER: Victor AR 

PROVIDER: S-EPMC5881939 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature