Analysis of essential gene dynamics under antibiotic stress in Streptococcus sanguinis.

ABSTRACT: The paradoxical response of Streptococcus sanguinis to drugs prescribed for dental and clinical practices has complicated treatment guidelines and raised the need for further investigation. We conducted a high throughput study on concomitant transcriptome and proteome dynamics in a time course to assess S. sanguinis behaviour under a sub-inhibitory concentration of ampicillin. Temporal changes at the transcriptome and proteome level were monitored to cover essential genes and proteins over a physiological map of intricate pathways. Our findings revealed that translation was the functional category in S. sanguinis that was most enriched in essential proteins. Moreover, essential proteins in this category demonstrated the greatest conservation across 2774 bacterial proteomes, in comparison t

SUBMITTER: El-Rami F 

PROVIDER: S-EPMC5882076 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature