Denture-associated biofilm infection in three-dimensional oral mucosal tissue models.

ABSTRACT: PURPOSE:In vitro analyses of virulence, pathogenicity and associated host cell responses are important components in the study of biofilm infections. The Candida-related infection, denture-associated oral candidosis, affects up to 60 % of denture wearers and manifests as inflammation of palatal tissues contacting the denture-fitting surface. Commercially available three-dimensional tissue models can be used to study infection, but their use is limited for many academic research institutions, primarily because of the substantial purchase costs. The aim of this study was to develop and evaluate the use of in vitro tissue models to assess infections by biofilms on acrylic surfaces through tissue damage and Candida albicans virulence gene expression. METHODOLOGY:In vitro models were compared a

SUBMITTER: Morse DJ 

PROVIDER: S-EPMC5882079 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature